Welcome to the Jiang Lab

 We are recruiting Postdocs, Visiting scholars, and Technicians. Please email us if you are interested.

The Jiang lab at the UNC HIV Cure Center and the Department of Biochemistry & Biophysics aims to understand the molecular mechanisms of stable HIV reservoirs in the resident immune cells of people with HIV (PWH). We focus on how HIV transcription is regulated during active HIV transcription and HIV latency in both peripheral compartments, such as PBMCs and the spleen, and the central nervous system. The traditional approaches of biochemistry, molecular biology, and virology are used for these studies, while many state-of-the-art technologies are applied to address the extremely challenging questions of HIV persistence, including quantitative proteomics, sc/sn/spatial RNA-seq, ATAC-seq, CUT&RUN, CRISPR KO, CryoEM, and AI/ML. Currently, a few animal studies are being planned for the eradication of HIV in vivo. The goal is to translate our understanding of HIV persistence into therapeutic interventions for a cure for HIV. We welcome postdocs and visiting scholars seeking training in epigenetics, chemical biology, signaling transduction, HIV immunology/virology, and neuroimmunology using advanced models of HIV infection and latency.

The Jiang Lab is actively supported by the National Institute of Mental Health (NIMH) through grant R01MH136852 and R01MH139446-01A1, the National Institute of Allergy and Infectious Diseases (NIAID) through grant R01AI186609, and the CARE Program through grant UM1AI164567.

Donate to support our studies? Please contact Dr. Jiang at Guochun_Jiang@med.unc.edu