Welcome to the Jiang Lab

The Jiang lab at the UNC HIV Cure Center and BCBP aims to understand the molecular mechanisms of stable HIV reservoirs in the resident immune cells of people with HIV (PWH). We focus on how HIV transcription machinery is regulated during active HIV transcription and HIV latency. Many in vitro, ex vivo, and in vivo models of HIV infection and latency are being pursued, including HIV-infected humanized mouse models, SIV-infected rhesus macaques, and PWH on ART. We are interested in mechanisms of stable HIV reservoirs in both peripheral compartments, such as PBMCs, the spleen and the liver, and the central nervous system. The traditional biochemistry, molecular biology, and virology approaches are used for these studies while many modern omics analyses are actively explored to address the extremely challenging questions of HIV cure. The ultimate goal is to translate our understanding of HIV persistence into therapeutic interventions for a cure of HIV. Additionally, the Jiang lab is actively studying the pathogenesis of other viruses, including HTLV-1 and human endogenous retroviruses. We welcome students who want to be trained in epigenetics, signaling transduction, immunology/virology of HIV, neuroscience, and neuroinflammation in advanced models of HIV latency.

The Jiang Lab is actively supported by the National Institute of Mental Health (NIMH) through grant R01MH136852, the National Institute of Allergy and Infectious Diseases (NIAID) through grants R01AI186609 and R21AI167709, the CARE Program (UM1AI164567), and B-HIVE (U54AI170855). Additionally, we receive funding from our collaborators, including the National Institute on Drug Abuse (NIDA) through grant R01DA055491, the National Institute of Neurological Disorders and Stroke (NINDS) through grant R01NS137852, and NIMH through grant R01MH136952.