Pubmed Search

Books and Chapters:

Guochun Jiang, Shailesh Choudhary, and David M. Margolis. Nov, 2007. “Molecular mechanisms of persistent proviral HIV-1 infection.” in “Persistent and Latent Infection by HIV-1 and Related Lentiviruses, 2007: ISBN: 978-308-0189-6 Editor: Amanda Brown”.

Patents:

Guochun Jiang and Satya Dandekar, “Disruption of HIV Latency by PEP005 (Ingenol-3-Angelate) Alone or Combined with other Anti-HIV Latency Agents”, Publication No. WO2016022358 A1.

Guochun Jiang and Satya Dandekar. “Methods of reactivating latent human immunodeficiency virus and related compositions”. Publication No. WO2019046594.

Selected Publications:

Tang Y, Woodward BO, Pastor L, George AM, Petrechko O, Nouvet FJ, Haas DW, Jiang G* and Hildreth JEK. Endogenous retroviral envelope syncytin induces HIV-1 spreading and establishes HIV reservoirs in placenta. Cell Reports, 2020, 30, 4528–4539 (*, co-corresponding author and Lead contact).

Yang H, Li X, Yang X, Lu P, Wang Y, Jiang Z, Pan H, Zhao L, Zhu Y, Khan I, Shen Y, Lu H, Zhang T, Jiang G, Ma Z, Wu H, Zhu H. Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections. Antiviral Res. 2019 Sep; 169:104555. doi: 10.1016/j.antiviral.2019.104555. PMID: 31295520.

Elsheikh MM, Tang Y, Li D, and Jiang G*, Deep latency: A new insight into a functional cure of HIV, EBioMedicine 2019 Jul;45:624-629. doi: 10.1016/j.ebiom.2019.06.020 (* corresponding author).

Crakes KR, Jiang G*. Gut microbiome alterations during HIV/SIV infection: Implications for HIV Cure. Front. Microbiol, 22 May 2019 | https://doi.org/10.3389/fmicb.2019.01104 (* corresponding author).

Jiang G, Maverakis E, Cheng MY, Elsheikh ME, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O’Connor DJ, Thompson GR III, Estes JD, Wong JK and Dandekar S, Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019; 4(7):e126027. PMID: 30944245

Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O’Connor DJ, Dandekar S. Subclinical cytomegalovirus infection associates with altered host immunity, gut microbiota and vaccine responses. J Virol, 2018 Apr 18. pii: JVI.00167-18. doi: 10.1128/JVI.00167-18.

Tang Y, George AM, Petrechko O, Nouvet FJ, Sweet SD, Tanaka Y, Imbiakha BS, Jiang G, Gao W, Anastos K, Hildreth JEK. Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1-HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1. mSphere, 2018 Apr 4;3(2). pii: e00038-18. doi: 10.1128/mSphere.00038-18.

Jiang G, Nguyen D, Archin NM, Yukl, SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR 3rd, Hartigan-O’Connor, DJ, Margolis DM, Wong JK, Dandekar S. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest, 2018 Feb 19. pii: 98071. doi: 10.1172/JCI98071.

Jiang G, Santos Rocha C, Hirao LA, Mendes EA, Tang Y, Thompson GR 3rd, Wong JK, Dandekar S. HIV exploits anti-viral host innate GCN2-ATF4 signaling for establishing viral replication early in infection. mBio, 2017 May 2;8(3). pii: e01518-16. doi: 10.1128/mBio.01518-16.

Glavan TW, Gaulke CA, Santos Rocha C, Sankaran-Walters S, Hirao LA, Raffatellu M, Jiang G, Bäumler AJ, Goulart LR, Dandekar S. Gut mucosal dysfunction through impaired pattern recognition receptor expression and gut microbiota changes in chronic SIV infection. Mucosal Immunol. 2015 Sep 16. doi: 10.1038/mi.2015.92.

Jiang G, Mendes EA, Kaiser P, Tang Y, Cai I, Melcher GP, Thompson GR 3rd, James E.K. Hildreth, Wong JK, Dandekar S. Synergistic reactivation of latent HIV expression by Ingenol-3-angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation. PLoS Pathogens | DOI:10.1371/journal.ppat.1005066 July 30, 2015.

Jiang G, Dandekar S. Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency. AIDS Res Hum Retroviruses. 2015 Jan;31(1):4-12. doi: 10.1089/AID.2014.0199. PMID: 25287643.

Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR 3rd, Tanuri A, Pianowski LF, Wong JK, Dandekar S. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS. 2014 May 6. PMID: 24804860.

Gaulke CA, Porter M, Han YH, Sankaran-Walters S, Grishina I, George MD, Dang AT, Ding SW, Jiang G, Korf I, Dandekar S. Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections. J Virol. 2014 Jun;88(11):6268-80. doi: 10.1128/JVI.00097-14. PMID: 24672033.

Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010 Nov 16;18(5):436-47. doi: 10.1016/j.ccr.2010.10.022. PMID: 21075309.

Yang ES*, Wang H*, Jiang G, Nowsheen S, Fu A, Hallahan DE, Xia F. Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice. J Clin Invest. 2009 May;119(5):1124-35. PMID: 19425167 (* equal contribution).

Jiang G, Espeseth A, Hazuda DJ, Margolis DM. c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol. 2007 Oct;81(20):10914-23. PMID: 17670825.

Jiang G, Sancar A. Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences. Mol Cell Biol. 2006 Jan;26(1):39-49. PMID: 16354678.