Publications
Books and Chapters:
Lilly M. Wong and Guochun Jiang. Aug, 2021. “Clinical Eradication of Latent HIV Reservoirs: Where are we now?” in the Frontiers in Clinical Drug Research: HIV. ISBN: 978-981-14-6443-0. Editor: Dr. Atta-ur-Rahman, University of Cambridge.
Guochun Jiang, Shailesh Choudhary, and David M. Margolis. Nov, 2007. “Molecular mechanisms of persistent proviral HIV-1 infection.” in the Section of “Persistent and Latent Infection by HIV-1 and Related Lentiviruses, 2007: ISBN: 978-308-0189-6 Editor: Amanda Brown”.
Patents:
Guochun Jiang and Satya Dandekar. “Methods of reactivating latent human immunodeficiency virus and related compositions”. Publication No. WO2019046594.
Guochun Jiang and Satya Dandekar, “Disruption of HIV Latency by PEP005 (Ingenol-3-Angelate) Alone or Combined with other Anti-HIV Latency Agents”, Publication No. WO2016022358 A1.
Selected Publications:
Mendes EA, Tang Y, and Jiang G*. The integrated stress response signaling during the persistent HIV infection. iScience. November 08, 2023. DOI:https://doi.org/10.1016/j.isci.2023.108418. In press. (*, corresponding author).
Tang Y*, Chaillon A, Gianella S, Wong LM, Li D, Simermeyer TL, Porrachia M, Ignacio C, Woodworth B, Zhong D, Du J, de la Parra Polina E, Kirchherr J, Allard B, Clohosey ML, Moeser M, Sondgeroth AL, Whitehill GD, Singh V, Dashti A, Smith DM, Eron JJ, Bar KJ, Chahroudi A, Joseph SB, Archin NM, Margolis DM, . Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy. J Clin Invest. 2023 Jun 15;133(12):e167417. doi: 10.1172/JCI167417.PMID: 37317962 (*, corresponding author)(Reported in MedicalExpress and UNC Healthcare; interviewed by BioArtMED, Managed Healthcare Executive, and Texerepublishing)
Zhu Z, Johnson RL, Zhang Z, Herring LE, , Damania B, James LI, Liu P. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cell Mol Life Sci. 2023 May 14;80(6):149. doi: 10.1007/s00018-023-04796-7.
PMID: 37183204.
Depletion of HIV reservoir by activation of ISR signaling in resting CD4+ T cells. iScience. 2022 Dec 7;26(1):105743. doi: 10.1016/j.isci.2022.105743. PMID: 36590168 (*, corresponding author).
Curr HIV/AIDS Rep. 2022 Dec;19(6):566-579. doi: 10.1007/s11904-022-00628-8. PMID: 36260191 (An invited review article by CHAR).
Tang Y and Jiang G*. Eradication of human immunodeficiency virus-1 in the brain microglia. Neural Regeneration Research. 2023, 18(3):552-553. doi: 10.4103/1673-5374.350198 (An invited review/prospective article. (*, corresponding author).
Ding H, George S, Leng X, Ihnat M, Ma J, Jiang G, Margolis DM, Dumond J, Zhang Y. Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity. Materials Today Advances. 2022; 15: 100261. https://doi.org/10.1016/j.mtadv.2022.100261.
Ding H, Jambunathan K, Jiang G, Margolis DM, Leng I, Ihnat M, Ma JX, Mirsalis J, Zhang Y. 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity. Pharmaceutics. 2022 May 11;14(5):1042. doi: 10.3390/pharmaceutics14051042. PMID: 35631624.
Shah S#, Wong LM#, Ellis K#, Bondar B, Saribas S, Ting J, Wei Z, Tang Y, Wang X, Wang H, Ling B, Margolis DM, Garcia JV, Hu W* and Jiang G*. Microglia-specific promoter activities of human HexB gene. Frontiers in Cellular Neuroscience. 2022 Mar 10; 16:808598. doi: 10.3389/fncel.2022.808598. PMID: 35360489 (# equal contributions to this study; *, corresponding author).
Wong LM, Li D, Tang Y, Méndez-Lagares G, Thompson GR III, Hartigan-O’Connor DJ, Dandekar S, and Jiang G*. HIV latency reversal via the induction of EGR1 to bypass PKC agonist-associated immune activation. Frontiers in Microbiology (In Press; *, corresponding author).
Li D, Dewey MG, Wang L, Falcinelli SD, Wong LM, Tang Y, Browne EP, Chen X, Archin NM, Margolis DM, Jiang G*. Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52. iScience. 2021 Dec 18; 25(1):103649. doi: 10.1016/j.isci.2021.103649. PMID: 35024584 (*, corresponding author).
Wong, LM, Jiang, G*. A Plausible Link of TMPRSS2/ACE2/AR Signaling to Male Mortality during the COVID-19 Pandemic in the United States. Pathogens 2021, 10, 1378. https://doi.org/10.3390/pathogens10111378 (*, corresponding author).
Su S, Chen J, Wang Y, Wong LM, Zhu Z, Jiang G & Liu P. Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses. Signal Transduct Target Ther. 2021 May 10;6(1):182. doi: 10.1038/s41392-021-00608-1. PMID: 33972500. (Reported in MedicalExpress and UNC Healthcare; interviewed by Nexstar Media Inc.)
Gascon MR, Lima M, Cheutchuk PC, Oliveira EA, de Oliveira GS, Gualqui CF, Luiz AM, Fonseca LAM, Magri M, Ferreira MD, Veiga APR, Monteiro MA, Tang Y, Jiang G, Duarte AJS, Cysique L, and Casseb J. High prevalence of HIV-associated neurocognitive disorders (HAND) in São Paulo City, Brazil. Rev. Bras. Neurol. 2021, 57(1): 6-12.
Wong LM, Jiang G*. NF-κB sub-pathways and HIV cure: A revisit. EBioMedicine. 2021 Jan;63:103159. doi: 10.1016/j.ebiom.2020.103159. Epub 2020 Dec 16. PMID: 33340992 (*, corresponding author).
Yang X, Wang Y, Lu P, Shen Y, Zhao X, Zhu Y, Jiang Z, Yang H, Pan H, Zhao L, Zhong Y, Wang J, Liang Z, Shen X, Lu D, Jiang S, Xu J, Wu H, Lu H, Jiang G, Zhu H. PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling. EMBO Reports. 2020 Sep 14;e49305. doi: 10.15252/embr.201949305.
Tang Y, Woodward BO, Pastor L, George AM, Petrechko O, Nouvet FJ, Haas DW, Jiang G* and Hildreth JEK. Endogenous retroviral envelope syncytin induces HIV-1 spreading and establishes HIV reservoirs in placenta. Cell Reports, 2020, 30, 4528–4539 (*, co-corresponding author and Lead contact).
Yang H, Li X, Yang X, Lu P, Wang Y, Jiang Z, Pan H, Zhao L, Zhu Y, Khan I, Shen Y, Lu H, Zhang T, Jiang G, Ma Z, Wu H, Zhu H. Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections. Antiviral Res. 2019 Sep; 169:104555. doi: 10.1016/j.antiviral.2019.104555. PMID: 31295520.
Elsheikh MM, Tang Y, Li D, and Jiang G*, Deep latency: A new insight into a functional cure of HIV, EBioMedicine 2019 Jul;45:624-629. doi: 10.1016/j.ebiom.2019.06.020 (*, corresponding author).
Crakes KR, Jiang G*. Gut microbiome alterations during HIV/SIV infection: Implications for HIV Cure. Front. Microbiol, 22 May 2019 | https://doi.org/10.3389/fmicb.2019.01104 (*, corresponding author).
Jiang G, Maverakis E, Cheng MY, Elsheikh ME, Deleage C, Méndez-Lagares G, Shimoda M, Yukl SA, Hartigan-O’Connor DJ, Thompson GR III, Estes JD, Wong JK and Dandekar S, Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate. JCI Insight. 2019; 4(7):e126027. PMID: 30944245
Santos Rocha C, Hirao LA, Weber MG, Méndez-Lagares G, Chang WLW, Jiang G, Deere JD, Sparger EE, Roberts J, Barry PA, Hartigan-O’Connor DJ, Dandekar S. Subclinical cytomegalovirus infection associates with altered host immunity, gut microbiota and vaccine responses. J Virol, 2018 Apr 18. pii: JVI.00167-18. doi: 10.1128/JVI.00167-18.
Tang Y, George AM, Petrechko O, Nouvet FJ, Sweet SD, Tanaka Y, Imbiakha BS, Jiang G, Gao W, Anastos K, Hildreth JEK. Pseudotyping of HIV-1 with Human T-Lymphotropic Virus 1 (HTLV-1) Envelope Glycoprotein during HIV-1-HTLV-1 Coinfection Facilitates Direct HIV-1 Infection of Female Genital Epithelial Cells: Implications for Sexual Transmission of HIV-1. mSphere, 2018 Apr 4;3(2). pii: e00038-18. doi: 10.1128/mSphere.00038-18.
Jiang G, Nguyen D, Archin NM, Yukl, SA, Méndez-Lagares G, Tang Y, Elsheikh MM, Thompson GR 3rd, Hartigan-O’Connor, DJ, Margolis DM, Wong JK, Dandekar S. HIV latency is reversed by ACSS2-driven histone crotonylation. J Clin Invest, 2018 Feb 19. pii: 98071. doi: 10.1172/JCI98071.
Jiang G, Santos Rocha C, Hirao LA, Mendes EA, Tang Y, Thompson GR 3rd, Wong JK, Dandekar S. HIV exploits anti-viral host innate GCN2-ATF4 signaling for establishing viral replication early in infection. mBio, 2017 May 2;8(3). pii: e01518-16. doi: 10.1128/mBio.01518-16.
Glavan TW, Gaulke CA, Santos Rocha C, Sankaran-Walters S, Hirao LA, Raffatellu M, Jiang G, Bäumler AJ, Goulart LR, Dandekar S. Gut mucosal dysfunction through impaired pattern recognition receptor expression and gut microbiota changes in chronic SIV infection. Mucosal Immunol. 2015 Sep 16. doi: 10.1038/mi.2015.92.
Jiang G, Mendes EA, Kaiser P, Tang Y, Cai I, Melcher GP, Thompson GR 3rd, James E.K. Hildreth, Wong JK, Dandekar S. Synergistic reactivation of latent HIV expression by Ingenol-3-angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation. PLoS Pathogens | DOI:10.1371/journal.ppat.1005066 July 30, 2015.
Jiang G, Dandekar S. Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency. AIDS Res Hum Retroviruses. 2015 Jan;31(1):4-12. doi: 10.1089/AID.2014.0199. PMID: 25287643.
Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR 3rd, Tanuri A, Pianowski LF, Wong JK, Dandekar S. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS. 2014 May 6. PMID: 24804860.
Gaulke CA, Porter M, Han YH, Sankaran-Walters S, Grishina I, George MD, Dang AT, Ding SW, Jiang G, Korf I, Dandekar S. Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections. J Virol. 2014 Jun;88(11):6268-80. doi: 10.1128/JVI.00097-14. PMID: 24672033.
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010 Nov 16;18(5):436-47. doi: 10.1016/j.ccr.2010.10.022. PMID: 21075309.
Yang ES*, Wang H*, Jiang G, Nowsheen S, Fu A, Hallahan DE, Xia F. Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice. J Clin Invest. 2009 May;119(5):1124-35. PMID: 19425167 (* equal contribution).
Jiang G, Espeseth A, Hazuda DJ, Margolis DM. c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol. 2007 Oct;81(20):10914-23. PMID: 17670825.
Jiang G, Sancar A. Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences. Mol Cell Biol. 2006 Jan;26(1):39-49. PMID: 16354678.