Welcome to the Jiang Lab

The Jiang lab at the UNC HIV Cure Center and BCBP aims to understand the molecular mechanisms of stable HIV reservoirs in the resident immune cells of people with HIV (PWH) on antiretroviral therapy (ART). We focus on how HIV transcription machinery is regulated during active HIV transcription and HIV latency. Many in vitro, ex vivo, and in vivo models of HIV infection and latency are being pursued, including HIV-infected humanized mouse models, SIV-infected rhesus macaques, and PWH on ART. We are interested in mechanisms of stable HIV reservoirs in both the peripheral compartments, such as PBMCs, the spleen and the liver, and the central nervous system, including the brain. The traditional biochemistry, molecular biology, and virology approaches are being applied to these studies while many modern omics analyses are actively explored to address the extremely challenging questions of HIV cure. The ultimate goal is to translate our understanding of HIV persistence into therapeutic interventions for a cure of HIV. Additionally, the Jiang lab is actively studying pathogenesis of other viruses, including HTLV and human endogenous retroviruses (HERVs).  We welcome students and postdocs who want to have training in epigenetics, signaling transduction, immunology and virology of HIV, neuroscience, and neuroinflammation in advanced models of HIV latency.